Thy1 promoter neurons
WebbI am currently a research assistant professor in the department of neurology at Northwestern University's Feinberg School of Medicine. My research examines mechanisms of toxicity in Parkinson's ... WebbHighly-motivated senior scientist with fourteen years of experience in cellular and molecular neuroscience • Experienced in coordinating collaborative interdisciplinary projects using in vivo as well as 2D and 3D in vitro assays, supervising postdocs, PhD students and laboratory technicians • Trained in designing experiments, testing …
Thy1 promoter neurons
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Webb11 okt. 2024 · In addition, we show that Thy1-jRGECO1a transgenic mice are useful for transcranial population imaging and functional mapping using widefield fluorescence … WebbSocial Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease ... the Thy1-aSyn ("Line 61") mice Neurotherapeutics Apr 2012 Other authors. See ... (neuronal cell cultures) and in vivo (mouse brain) Jul 2013 - Dec 2015. ...
WebbEnter the email address you signed up with and we'll email you a reset link. Thy-1 expression in the brain is developmentally regulated. Thy-1 levels in the neonatal rat brain, as well as the developing human brain, are low compared to adult brain. During the first few weeks of postnatal development, Thy-1 levels increase exponentially as the brain matures. Visa mer Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a Visa mer The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search for heterologous antisera against mouse leukemia cells, and was demonstrated by them to be present on murine thymocytes, … Visa mer Thy-1 is one of the most heavily glycosylated membrane proteins with a carbohydrate content up to 30% of its molecular mass. Thy1 in most species has 3 N-glycosylation sites (Asn 23, 74 and 98) but no O-glycosylation. The composition of Thy-1 … Visa mer As a GPI-anchored protein, Thy-1 is present in the outer leaflet of lipid rafts in the cell membrane. In case of neurons it is known to be expressed … Visa mer Thy-1 has been conserved throughout vertebrate evolution and even in some invertebrates, with homologs described in many species like squid, frogs, chickens, mice Visa mer The 25-kDa core protein (excluding the heavy glycosylation) of rodent Thy-1 is 111 or 112 amino acids in length, and is N-glycosylated at three sites (In contrast to only two … Visa mer Thy1 expression varies between species. Amongst the cells reported to generally express Thy-1 are thymocytes (precursor of T cells in the thymus) & CD34(+) prothymocytes; Visa mer
Webb10 juni 2011 · In SLICK-H mice, the Thy1 promoter drives robust and relatively uniform expression of a drug-inducible form of cre recombinase throughout the peripheral and central nervous system. This permits efficient induction of cre-mediated genetic manipulation upon tamoxifen administration in adult mice. Webb29 jan. 2015 · The retina of mice expressing cyan fluorescent protein under control of the Thy-1 promoter (Thy1-CFP mice) ... Fluorescent neurons were counted in the same defined retinal areas imaged at each ...
WebbThe encoded prot ein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein …
WebbThy1-YFP-16 mice express yellow fluorescent protein driven by a mouse Thy1 promoter, which labels sensory and motor neurons as well as subsets of central neurons. This line provides a strong and specific vital marker for axons. No expression is detectable in nonneural cells. All experiments were conducted on Thy1-YFP expressing mice. early heaume helmetWebb24 sep. 2014 · Thy1 transgenics can exhibit transgene expression in specific subsets of cortical projection neurons . In GP5.3 mice L2, but not L3 cells, were labeled over large parts of the cortex; in the neocortex of … early heart attack warningsWebb11 apr. 2024 · The Thy1 promoter shows selective expression in the ganglion cell layer of the retina [10,11]. We have included this information in our manuscript (Results – High-resolution in vivo imaging of retinal pharmacology, line 307-308): “The rd1-Thy1-GCaMP6s mice selectively express GCaMP6s in their RGC layer of the retina 63,64 ” References: 1 ... early heating and coolingWebb2 juli 2024 · Background: Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. GC is a pathologically and molecularly heterogeneous disease. DNA hypermethylation in promoter CpG islands causes silencing of tumor-suppressor genes and thus contributes to gastric carcinogenesis. In addition, various molecular … early heart attack symptoms in womenWebb27 nov. 2024 · Protein aggregation and accumulation are common pathological hallmarks in neurodegenerative diseases. To efficiently clear and eliminate such aggregation becomes an important cellular strategy for cell survival. Lewy bodies inclusion and aggregation of α-Synuclein (α-Syn) during the pathogenesis of Parkinson’s disease (PD) … early heavy bombardmentWebb18 jan. 2015 · Females express somewhat more APP than males, probably due to an estrogen response element in the Thy1 promoter used to drive transgene expression ( Sadleir et al., 2015; Sadleir et al., 2024 ), and generate higher levels of Aβ ( Oakley et al., 2006; Maarouf et al., 2013 ). cst inc memoryWebb6 apr. 2024 · Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or … cst in chemistry