Web12 Feb 2024 · SMURF1 increases ER alpha stability, possibly by inhibiting K48-specific poly-ubiquitination process on ER alpha protein. Interestingly, SMURF1 expression could be … WebIntroduction. Chronic obstructive pulmonary disease (COPD), characterized by persistent respiratory symptoms, progressive airflow limitation, and lack of effective treatment, is one of the leading cause of morbidity and mortality all over the world. 1,2 In China, two national surveys of COPD showed that the overall prevalence of COPD in people aged 40 years or …
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WebSMURF1 acts as a tumor promoter by ubiquitination modification and/or degradation of tumor-suppressing proteins. Combined treatment of Smurf1 knockdown with rapamycin … WebHigh affinity Smurf1 inhibitor; enhances BMP signaling: 5747: Apcin: Cdc20 inhibitor; inhibits Cdc20-substrate interaction: 7715: C25-140 New: TRAF6-Ubc13 interaction … marginalisation of people with autism
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WebThe proteasome inhibitor MG132 (Sigma–Aldrich; 474787) was used at a final concentration of 5 μM. A selective small molecule kinase inhibitor of TβRI (SB431542; SB; Laping et al, 2002) was used at a concentration of 10 μM. Recombinant TGF-β3 and recombinant BMP6 were kind gifts from Andrew Hinck (University of Pittsburgh) and … WebChemical Name. [4- [ [4-Chloro-3- (trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl] [4- (5-methyl-1H-pyrazol-1-yl)phenyl]methanone. Biological Activity. High affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in ... Web7 Mar 2024 · One of these, Smad-specific E3 ubiquitin protein ligase 1 (Smurf1), was particularly intriguing given a previous link to activin and Smad signaling , along with availability of a selective small-molecule inhibitor. Smurf1 inhibition recapitulated the benefits of MG132 in blocking activin A–induced reductions in SERCA2a protein, … kuta function inverses