Web20 jun. 2016 · We developed a mouse model, Tg(KRT14-cre/Esr1) (20Efu/J) × Sod2 (tm1Smel) , that generates mitochondrial oxidative stress in keratin 14-expressing epidermal stem/progenitor cells in a temporally … Web20 jul. 2024 · Krt14-cre transgene was expressed in the epidermis and hair follicles (and other epidermal structures) similar to immunohistochemical localization of KRT14 . S100 …
【小鼠大学问】诱导型Cre,给基因敲除装个“开关” - 知乎
Web24 jun. 2011 · We therefore generated mice in which diphtheria toxin A (DTA) was conditionally expressed in basal cells of stratified epithelia by crossing the ROSA26-tm-DTA mouse (Ivanova et al., 2005) with one having a Tamoxifen-dependent Cre recombinase under the control of the Krt14 promoter (Vasioukhin et al., 1999) (hereafter the DTA … WebCre 蛋白是一种重组酶,是causes recombination的缩写,于1981 年从 P1 噬菌体中被发现,属于 λInt 酶超基因家族。 Cre 重组酶基因编码区序列全长1029bp,编码 38kDa 蛋白 … dr kenneth holliman torrance ca
Cre recombinase induces DNA damage and tetraploidy in the …
Web10 dec. 2024 · We crossed this genetic model with keratin 14 Cre (Krt14-Cre)–expressing mice to generate mice with epidermal deletions of Mll4 (Krt14-Cre; Mll4 fl/fl or “Mll4-eKO”) (fig. S1A). Mll4-eKO mice were born in the expected Mendelian ratios (fig. S1B) with no visible differences from littermate controls during the first week of life. Web22 nov. 2024 · Conditional deletion of PKK in keratinocytes. (A) Genotyping of tail DNA identifies the C57BL6;129F10-PKK tm1 floxed allele (F) as 413 base pairs compared … Web21 mrt. 2024 · KRT14 (Keratin 14) is a Protein Coding gene. Diseases associated with KRT14 include Dermatopathia Pigmentosa Reticularis and Naegeli-Franceschetti … dr kenneth haynes in corpus christi tx