WebMay 29, 2024 · PDF Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. ... Thus, ISGylation is critical for optimal and efficient OXPHOS by ensuring the ... WebMay 29, 2024 · Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSCs are extremely plastic and can successfully adapt to targeted therapies. ... Loss of ISG15/ISGylation alters mitochondrial …
ISG15 induces ESRP1 to inhibit lung adenocarcinoma progression
WebMay 29, 2024 · The ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISGylation. Here, the authors show that ISGylation is necessary for pancreatic … WebMeanwhile, RIG-I could promote ISGylation by up-regulating the key genes in the ISGylation pathway through cooperation with STAT1/2 and IRF1. The integrity of ISGylation was essential in ATRA or RIG-I–induced differentiation. ... (FDA) for the treatment of cutaneous T cell lymphoma, could inhibit the growth of lung cancer cells by inducing ... dry cleaning blood stains
Cancers Free Full-Text ISG15 Promotes ERK1 ISGylation, CD8
WebDec 1, 2012 · It is evident that the relationships between ISGylation and cancer are complex and far from being understood, with different implications depending from the neoplastic context. As a first step to clarify whether ISGylation is friend or foe [89] , it is important to understand whether up-regulation of the ISGylation machinery is avidly supported ... WebHowever, recently, new functions of ISGylation have emerged that implicate it in multiple cellular processes, such as DNA repair, autophagy, protein translation and exosome secretion. In this Review, we discuss the induction and conjugation of ISG15, as well as the functions of ISGylation in the prevention of infections and in cancer progression. WebGlycoprotein 90K (also known as LGALS3BP or Mac-2BP) is a tumor-associated protein, and high 90K levels are associated with poor prognosis in some cancers. To clarify the role of 90K as an indicator for poor prognosis and metastasis in epithelial cancers, the present study investigated the effect of 90K on an adherens junctional protein, E-cadherin, which … dry cleaning bloomington indiana