Irf4 flow
WebMay 15, 2014 · Loss of interferon regulatory factor 4 (IRF4) specifically in the myeloid cells evoked a constitutive M1 polarization in the adipose tissue, suggesting that IRF4 is a negative regulator of inflammation in diet-induced obesity, in part through regulation of macrophage polarization ( 14 ). WebJun 11, 2006 · Indeed, IRF4, originally identified also as the product of a proto-oncogene involved in chromosomal translocations in multiple myeloma, is capable of transforming cells in vitro 15 and is often...
Irf4 flow
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WebTel +86 13607141618. Email [email protected]. Background: Therapeutic hypothermia (TH) has been proven to be protective in ischemic stroke (IS) due to its anti-inflammatory capacity. Recently, the interferon regulatory factor 4 (IRF4) has been characterized as a central regulator of neuroinflammation in IS. WebFlow cytometric analysis of IRF4 expression in human and mouse leucocytes. Human …
WebMay 24, 2024 · Our study suggests the regulatory activities of IRF4 and STAT3 are associated with the Th17-mediated inflammatory responses to PM exposure in the respiratory tracts, which informs the biological background of the immunogenicity of particulate matters. ... T-cell differentiation is evaluated by flow cytometry at 18 h, 24 h, 40 … WebMay 14, 2015 · We previously discovered a recurrent translocation in PTCL, t(6;14)(p25.3;q11.2), that juxtaposes the interferon regulatory factor-4 (IRF4) and T-cell receptor-α (TRA) genes and is associated with increased IRF4 expression. 6 Because TRA translocation partners typically function as oncogenes in T-cell malignancies, we …
WebApr 8, 2024 · Immunoglobulin-class distribution was evaluated within the PC population defined by the Blimp-1 + IRF4 + phenotype in flow cytometry in blood as well as lymphatic and non-lymphatic organs . A clear Blimp-1 + IRF4 + population was identified in all organs with highest frequencies in the spleen (1.93% ± 0.49) and the lung (1.97% ± 0.58, Figure ... WebDec 3, 2024 · AMI results from a sudden interruption of blood flow in the coronary artery, causing an ischaemic and hypoxic microenvironment in myocardial tissue and leading to cardiomyocyte necrosis and impaired heart function ... The mRNA level of Irf4 was also significantly decreased in sorted macrophages from Adk MAC-KO hearts compared to …
WebIRF4: A gene on chromosome 6p25-p23 that encodes a member of the interferon …
WebJun 18, 2024 · This protocol facilitates sensitive intranuclear flow cytometric … dtw to reagan airportWebAug 6, 2024 · Notably, an IRF4 rearrangement with a gain of the IRF4 gene was detected (panel I; FISH analysis with break-apart probes showed split red/green signals in 85% to 90% of tumor nuclei with a gain of the IRF4 gene, with an average of 3.5 and 3.4 red and green signals, respectively, per neoplastic cell; yellow arrows, normal alleles; red and green … dtw to ronald reaganWebOct 1, 2024 · Ischemia reperfusion injury (IRI) of the kidney results in interferon regulatory factor 4 (IRF4)–mediated counter-regulation of the acute inflammatory response. Beyond that, IRF4 exerts important functions in controlling the cytokine milieu, T-cell differentiation, and macrophage polarization. The latter has been implicated in tissue remodeling. It … common blog fontsWebSep 22, 2013 · IRF4 regulated the expression of key molecules required for the aerobic … common blind snakeWebIn addition, IRF4-deficient B cells had impaired expression of activation-induced … dtw to rapid cityWebNov 26, 2024 · IRF4 regulates transcription of genes that specify plasma cell identity • Induction of IRF4 deletion leads to BCL2-inhibitable apoptosis in plasma cells Summary The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasma cells. dtw to reagan nationalWebApr 11, 2024 · h Quantification of CD3 + EGFRt + STEAP1-BB ζ CAR T cells by flow cytometry from splenocytes of mice treated with STEAP1-BBζ CAR ... (cDC2, CD1 + IRF4 +), migratory CD103 + dendritic cells ... common block properties simulink