WebbUse of one or more markers to identify and sort cells that have been engineered to comprise a synthetic chromosome encoding the marker(s), with said cells expressing said marker(s) encoded on the synthetic chromosome. The marker is typically but not limited to a cluster of differentiation (CD), wherein the CD has been truncated or otherwise … WebbRecently, we have uncovered that inhibitors of apoptosis (IAPs) function as direct E3 ubiquitin ligases for Rho GTPase Rac1 and target it for proteasomal degradation. Here, …
Ubiquitin-dependent regulation of Cdc42 by XIAP - PMC
Webb1 maj 2012 · The Inhibitor of apoptosis (IAP) proteins are key negative regulators of cell death, whose amplification has been correlated with tumor progression. Due to the … WebbThe number of targets of IAP-mediated ubiquitylation is increasing and recent results indicate that outcomes following ubiquitylation are tantalizingly complex. As well as … ioc in react
IAPs, RINGs and ubiquitylation Nature Reviews Molecular Cell …
WebbHere we show that the RING domain of cIAP1 fingers, or SOCS boxes were cloned into pcDNA5 FRT TO allows it to bind directly to the RING of X-linked IAP, causing its … Webbscientific article Webb它们包括(1)免疫调节药物(IMiD),如沙利度胺和泊马度胺,它们结合cereblon(CRBN或CRL4CRBN)——滞蛋白(cullin)-RING泛素连接酶(CRL)复合物的组分(Bondeson等 … ons hout