Hepatic efflux transporter
WebHepatic efflux transporters include numerous well-known and emerging proteins localized to the canalicular or basolateral membrane of the hepatocyte that are responsible for the … Web1 sep. 2008 · COPPER EFFLUX TRANSPORTERS Import of copper by CTR1 does not require energy or a proton gradient, but efflux requires hydrolysis of ATP. Two well …
Hepatic efflux transporter
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Web1 okt. 2012 · Raloxifene exhibits a large and unexplained interindividual variability in its pharmacokinetics and pharmacodynamics.The aim of our study was to identify … WebMRP2 showed the highest efflux clearance of EG among these efflux transporters, whereas BCRP-mediated clearance of ES was the highest in these double transfectants. …
Web1 jul. 2024 · These phenomena suggest that glucuronides formed extrahepatically (such as in the intestine), available for hepatic uptake transporters (e.g. Organic Anion … Web23 okt. 2013 · Islatravir also demonstrated no inhibitory effect on the hepatic efflux transporters BSEP, MRP2, MRP3, and MRP4, which are involved in the hepatic efflux …
Web2 nov. 2024 · A significant reduction in expression and function of several hepatic uptake transporters, upregulation of many efflux transporters, downregulation of cholesterol … Web1 okt. 2024 · Hepatic efflux transporters consist of multidrug resistance proteins (MDRs), multidrug resistance-associated proteins (MRPs), breast cancer resistance protein …
Web1 dec. 2016 · Introduction. T he hepatocyte adaptive response has been implicated to play a protective role in cholestatic disease states, including primary biliary cirrhosis, a disease …
WebAmong the efflux transporters, inhibition of BSEP has been linked to cholestasis, both from known mutations resulting in genetic disease (e.g. familial intrahepatic … family and religious studies book 3Web5 sep. 2012 · Efflux transport proteins located in the basolateral and apical (canalicular) membranes of hepatocytes play an important role in the hepatic elimination of many … family and religionWebnide metabolites indicate that hepatic basolateral efflux transporters mediate their excretion. We aimed here to find the transporters responsible for the hepatic excre-tion … family and religious studies notes a levelWeb13 nov. 2024 · Inhibition of hepatic efflux transporters was investigated in 45 licensed DILI-causing and DILI-negative drugs. Our assay system demonstrated that the potency … cook a rump steakWebBiliary excretion of drug and metabolites involves one of several ATP-dependent transport proteins expressed on the canalicular membrane. These proteins are members of the … cook as a turkeyWebBasolateral efflux transporters MRP3 and MRP4 mediate excretion of parent drugs and, more commonly, polar metabolites from hepatocytes into blood. Basolateral … cook artichoke in ovenWebTrafficking of Hepatic Efflux Transporters. An important concept in transporter regulation is that of intracellular pools from which membrane transporters can be swiftly … family and religion in mexico