Genotoxicity of chromium compounds. a review
WebAbstract: Chromium is a widespread industrial waste. The soluble hexavalent chromium Cr (VI) is an environmental contaminant widely recognized to act as a carcinogen, mutagen and teratogen towards humans and animals. The fate of chromium in the environment is dependent on its oxidation state. Hexavalent chromium primarily enters the cells and WebThe available in vivo evidence suggests that genotoxic effects are very unlikely to occur in humans or animals exposed to nutritional or to moderate recommended supplemental …
Genotoxicity of chromium compounds. a review
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WebAt the genomic level, Cr genotoxicity manifests as gene mutations, several types of DNA lesions and inhibition of macromolecular synthesis. At the cellular level, Cr exposure may … WebThe available in vivo evidence suggests that genotoxic effects are very unlikely to occur in humans or animals exposed to nutritional or to moderate recommended supplemental levels of Cr (III). However, excessive intake of Cr (III) supplements does …
WebAug 11, 2014 · Taken together, our results suggest that both trivalent and hexavalent chromium compounds are genotoxic and that they cause DNA damage through different … WebPresent evidence indicates that the trivalent chromium compounds do not cause cancer although high concentrations in some in vitro systems have shown genetic toxicity. Hexavalent chromium compounds cause cancer in humans, in experimental animals and exert genetic toxicity in bacteria and in mammalian cells in vitro.
WebApr 12, 2024 · This review retraces the origins of chromium replacement motivations, introducing the various legislative actions aimed at diminishing the use of chromium … WebApr 12, 2024 · Although many avian studies have investigated the toxic effects of lead on important biochemical and physiological processes, organ and system function, and behavior, studies evaluating the specific genotoxic effects of exposure to lead are scarce. Nowadays, rapid technological advances can provide new molecular techniques in this …
WebFeb 4, 2024 · However, the results of CAPE co-incubation with the CPT-11 or SN38 indicated that CAPE decreased the genotoxic activity of both these compounds in all the cell types analyzed. The only exception was the HT29 cell line, where CAPE given along with CPT-11 increased genotoxicity compared to the series with CPT-11 alone, but the differences was …
WebSep 8, 2024 · Genotoxicity and carcinogenicity are already well known with regard to heavy metals, mainly due to their ability to induce DNA damage that can influence the carcinogenic process. The carcinogenic... companies house switch mobilityWebThe cytotoxicity of soluble and insoluble hexavalent chromium compounds to fibroblasts is 100-1000 times greater than that demonstrated by trivalent chromium compounds. In … companies house symbiosisWebThis page combines publications related to two different topics. Genotoxicity and Chromium Compounds. Science topic Genotoxicity. A topic description is not currently available. eating well with diabetes pdfWebW.J. Rogers, in Sterilisation of Biomaterials and Medical Devices, 2012 7.14.1 Genotoxicity – ISO 10993–3. Genotoxicity testing evaluates gene mutations, changes in chromosomes … eating wet fartsWebThe bioavailability and toxicity of chromium compounds has been reviewed by several institutions. Following oral administration, chromium(III) was reported to be very poorly absorbed via the gastrointestinal tract (0.4 to 2.8%) in both rats and humans. eating well with kidney diseaseWebGenotoxicity is the ability of specific substances to cause DNA damage, affecting development, physiology, and reproduction. This is often mediated by induction of oxidative stress. This in vitro study aims to test the ability of two antioxidants, ellagic acid (EA, 100 µM) and curcumin (Cur, 40 µM) to protect zebrafish blood cells from the genotoxic action … companies house synthiteWebApr 12, 2024 · This study aims to select fungi isolates to reduce olive mill wastewater (OMWW) chemical oxygen demand (COD) and phenolic compounds (PC), as well as their genotoxicity effect. Treatment with mold, isolated by an innovative technique using phenolic compound-selective media, showed a reduction rate of about 4% for COD and 2% for PC … eating well with type 2 diabetes pdf