Downregulation of fatty acid in cancer
WebThe importance of de novo fatty acid synthesis and fatty acid oxidation in cancer cells suggests fatty acid metabolism may be targeted for anticancer treatment through the … WebKey points: Fatty acid synthesis is upregulated in cancer. The mitochondrial citrate transporter protein (CTP) protects mitochondrial function in cancer. ATP citrate lyase (ACLY) is...
Downregulation of fatty acid in cancer
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WebNov 19, 2024 · Fatty acids (FAs) are essential biomolecules for all organisms. Their oxidation generates the highest energy yield for ATP or heat production of all common … WebMar 23, 2024 · The present study revealed impairment of lipid metabolism in papillae with calcified plaque tissue and down-regulation of fatty acid-binding protein 4 (FABP4) associated with plaque formation. Immunohistochemistry of human kidney specimens and experiments of nephrocalcinosis model mice and Fabp4 knockout mice validated FABP4 …
WebMar 17, 2024 · HIF-1α upregulation in human GA patients and AGS cells was paralleled by downregulation of lipid catabolism genes potentially via reduced PPARγ -mediated FAO. … WebJun 1, 2024 · The high-frequency downregulation of ACO2 suggests an important role of metabolic adaptations for CRC cell survival. Herein, we attempted to identify the …
WebThe saturated fatty acids significantly decreased whereas unsaturated fatty acids were increased after 13-cis-RA treatment in prostate cancer cells. This study demonstrates for the first time that retinoic acid mediated downregulation of saturated fatty acids and upregulation of unsaturated fatty acid in human prostate cancer cells. MeSH terms WebDec 30, 2015 · Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer Oncology Letters International Journal of Oncology Molecular and Clinical Oncology Experimental and Therapeutic Medicine International Journal of Molecular Medicine Biomedical Reports Oncology …
WebDec 30, 2015 · The aim of the present study was to investigate the effect of fatty acid synthase complex (FASN) on the migration capacity of bladder transitional cell …
WebUpregulation of acetyl-CoA carboxylase (ACC), as a rate-limiting enzyme of fatty acid synthesis,has been recognized in multiple human cancers, implicating a critical … malibu chili cook off ticketsWebJan 26, 2024 · Enhanced elongation of saturated fatty acids in CRC According to Kondo, CRC patients had significantly lower serum levels of long-chain FAs, 14:0, 15:0 and 18:0, and presented with significantly higher serum levels of very long-chain FAs (VLCFAs), 24:0, 25:0, 26:0, 28:0 and 30:0, than healthy controls [ 85 ]. malibu chest of drawersWebNational Center for Biotechnology Information malibu chili cook off 2022 ticketsWebApr 1, 2024 · Fatty acid transporter 3 (FATP3, also named as SLC27A3) plays a critical role in brain development and monocyte-macrophage differentiation. It has been reported … malibu chicken sandwich recipeWebBecause metabolic adaptation of breast cancer cells to the ambient fatty acid concentration may be relevant to the goal of utilizing FAS inhibition as a chemotherapeutic target, we evaluated the effect of exogenous dietary fatty acids on the cytotoxicity resulting from the inhibition of FAS activity. malibu chicken recipeWebNov 16, 2024 · Docosahexaenoic acid (DHA), an ω3-PUFA, was reported to inhibit growth and induce apoptotic and autophagic cell death in several cancer cell lines; however, its effects on GBM cells are still unknown. in the present study, we examined the cytotoxic effect of DHA on the GBM cell lines, D54MG, U87MG, U251MG and GL261. malibu chicken casseroleWebIntroduction. The excessive accumulation of lipids or lipid intermediates in non-adipose tissues, such as the liver and kidney, leads to cellular dysfunction and … malibu chili cook off and festival