Cyp46a1 protein
WebThe Cyp46a1 gene, which encodes cholesterol 24-hydroxylase, is expressed in only a small but specific subset of neurons in the brain. It was recently found that mice … WebApr 18, 2024 · The former point is indirectly supported by a study of the brain phosphoproteome of Cyp46a1 −/− mice, which showed a general decrease in protein phosphorylation , possibly as a result of altered targeting of protein kinases to their protein substrates and vice versa protein substrates to their kinases, which reside in lipid rafts. …
Cyp46a1 protein
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WebThis endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. ... CYP46A1 open_in_new. Ensembl ID . ENST00000261835 ... WebRecombinant Human CYP46A1 Protein [H00010858-Q01] - 12.5% SDS-PAGE Stained with Coomassie Blue. Product Details. Summary. Reactivity: Hu Species Glossary: Applications: WB, ELISA, PA, AP: Order Details 100% Guarantee on every product. Recombinant Human CYP46A1 GST (N-Term) Protein Summary ...
WebMar 22, 2024 · When Cyp46A1 was overexpressed in NIH3T3 cells, intrinsic oxysterols increased in the order 24S-HC > 25-HC > 27-HC. We investigated the mechanism regulating the production of endogenous oxysterols in NIH3T3 cells by Cyp46A1 and found that the mRNA, relative protein levels and enzymatic activity of Cyp46A1, and the amounts of … WebJul 9, 2024 · CYP46A1 improves behavioural and neuropathological phenotype in zQ175 mice In the zQ175 mice, a knock-in mouse model of Huntington’s disease with a …
WebNov 16, 2024 · The crystal structure of human CYP46A1 P450 with ligand cholesterol-3-sulphate bound (PDB: 2Q9F; X-ray diffraction 1.9 Å) and unliganded structure of the same protein (PDB: 2Q9G; X-ray diffraction … WebCholesterol 24-hydroxylase (CH24H or CYP46A1) is a brain-specific cytochrome P450 enzyme that metabolizes cholesterol into 24S-hydroxycholesterol (24HC) for regulating brain cholesterol homeostasis.
WebApr 18, 2024 · CYP46A1 transcription was found to be insensitive to major regulatory axes, except oxidative stress . Studies show that CYP46A1 may be controlled epigenetically …
WebCYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease CYP46A1 inhibition, brain cholesterol accumulation and … ford s-max hybrid testWebJul 16, 2013 · The CYP46A1 protein in the brain was located to neuronal cells. It is evident that there are very specific requirements for expression of this protein in different cells. Under normal conditions CYP46A1 protein is almost exclusively expressed in neuronal cells in the brain and in the eye. It seems likely that there a number of restrictions ... emanationistsWebAnti-CYP46A1抗体. Product Properties. Cat Code Product Name Clonality Cross reactivity Application MW(kDa). 508573 Anti-CYP46A1 Rabbit pAb Rabbit pAb Human,Mouse,Rat WB 57kDa. Sensitivity . Anti-CYP46A1抗体Immunogen Recombinant protein of human CYP46A1. Host Rabbit. Clone Number . Anti-CYP46A1抗体Antibody type Polyclonal … emanation of presenceWebJun 2, 2024 · The protein levels of (B) HMGCR, (D) ApoE and (F) CYP46A1 were measured by Western blots. Shown are representative blots for each protein with β-actin used as a loading control. ford s max kerb weightWebThe tissue cell type section describes the cell type specificity profile of each gene within a given tissue based on an integrative co-expression analysis of bulk RNAseq data. … ford s-max hybrid reviewWebAug 25, 2024 · Protein Data Bank in Europe. Bringing Structure to Biology. Examples: hemoglobin, BRCA1_HUMAN. ... Gene names: CYP46, CYP46A1 Sequence domains: Cytochrome P450. Ligands and Environments Cofactor: 1 x HEM. 1 bound ligand: 1 x YCJ. No modified residues. Experiments and Validation Details. emanating or emittingWebCytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified by efavirenz, the anti-HIV medication. Previously, we … emanating pronounce