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WebJan 11, 2024 · It is too easy to take too much of one individual medication if you take multiple combination products. Dayquil and Nyquil both contain acetaminophen, so if you take additional acetaminophen on top of that you can damage your liver. Advil/ibuprofen is in a different drug class than Tylenol/ibuprofen, so it is fine to combine ibuprofen doses ... WebSep 21, 2024 · DayQuil can be taken with or without food. Mucinex should be taken with food. DayQuil can be taken every four to six hours. Mucinex should be taken every twelve hours. It is important to follow the directions on the … WebMay 13, 2024 · Problems Taking NyQuil And DayQuil At The Same Time. The primary reason you don't want to take NyQuil and DayQuil at the same time is that they share some of the same drugs (e.g. dextromethorphan and acetaminophen). The big concern here is taking too much acetaminophen as both contain 650 mg per dose (a dose of either … clayton and foster accountants